A knowledge-based transmembrane topology predictor

The Localizome server predicts TM helix number and TM topology of a eukaryotic protein and presents the result as an intuitive graphic representation. It utilizes hmmpfam to detect the presence of Pfam domains, and a prediction algorithm, Phobius, to predict the TMhelices.

The result are combined and checked against the TM topology rules stored in a protein domain databases called LocaloDom.

                 

                  

  Sequence input (FASTA format)


       * The maximum number of input proteins in a single submission is 500 protein.

      * The length of each sequence is limited to 6,000 residues.


    Copy and Paste your protein sequences here.
    or, Select a sequence file you wish to use    
       

E-value cut-off (for hmmpfam) :  

   

E-mail address (>= 2 proteins)  : 

     * The results will be sent to the e-mail address, if a user inputs more than two proteins.

                           

Publication:
Localizome: a server for identifying transmembrane topologies and TM helices of eukaryotic proteins utilizing domain information. Nucleic Acids Research (2006). Vol. 34, W99-W103.